Projects

Michal Teplan

Project selection:

International projects

European network for advancing Electromagnetic hyperthermic medical technologies.
Európska sieť pre pokrok v elektromagnetických hypertermických medicínskych technológiách
Program: COST
Duration: 4.9.2018 – 3.3.2023
Project leader: Mgr. Teplan Michal, PhD.
Annotation: Electromagnetic (EM) hyperthermic technologies hold great potential in the treatment of diseases, especially for cancers that are resistant to standard regimens. These technologies modify tissue temperature: hyperthermia heats the diseased tissue to make it susceptible to treatments, and ablation heats the tissue until it is destroyed. Hyperthermia is particularly effective in treatment of cervical and breast cancer, head and neck cancers, sarcoma in adults, and germ cell tumours in children; while radiofrequency and microwave ablation offer promise for treating liver, kidney, and lung cancers.Overall, these techniques have shown significant potential and there is substantial opportunity to solidify their use clinically and to apply them to a wider range of medical conditions. However, underpinning the development of these techniques is the need for accurate knowledge of the dielectric and thermal properties of tissues, which provide the foundation for these technologies and de-risk the technical challenge before commercialization. Furthermore, contributing to the stagnant market of EM hyperthermic medical devices is the fact that, often researchers working on the development of medical technologies are not fully aware of, and not trained to address, the clinical and commercialisation challenges facing novel medical devices. To address these challenges, the MyWAVE Action takes a holistic approach by bringing together key players in the field of dielectric spectroscopy, translational research, and medical professionals. Conjoining these varied communities into one collaborative network is critical to advance the design, development, and commercialisation of EM hyperthermic technologies, so that they can reach patients faster and improve treatment outcomes.
Project website: www.cost.eu/actions/CA17115

National projects

Investigation of biomedical effects of low frequency and pulsed electromagnetic fields
Výskum biomedicínskych účinkov nízkofrekvenčných a pulzných elektromagnetických polí
Program: VEGA
Duration: 1.1.2022 – 31.12.2024
Project leader: Mgr. Teplan Michal, PhD.
Annotation: Although there is a persisting interest in both adverse and beneficial biological effects of electromagnetic fields(EMF), the unambiguous explanation of electromagnetic field influence on living structures is still lacking. For theimpact of low-frequency magnetic field (LF MF) experimental platform with monitoring of the cell growth curve based on impedance spectroscopy will test possible inhibition or stimulation dependent on the frequency and magnetic flux parameters. Effects of pulsed electric field (PEF) will be monitored by biological autoluminescence (BAL). Complexity measures will be utilized for ultrafast current recordings during the PEF application. For quantification of direct effects of PEF on microtubules (MT) and evaluation of kinesin molecule movement, advanced image processing methods will be developed. The relevance of this research area lies in theexploration of physical methods with possible contributions to diagnostics and therapy.