Projects

Milan Tyšler

Project selection:

National projects

Multi-lead ECG measurement to create a personalized model of the electric field of the heart and research the possibilities of its use for the diagnosis and optimization of cardiac arrhythmia therapy
Mnohozvodové meranie EKG na vytvorenie personalizovaného modelu elektrického poľa srdca a výskum možností jeho využitia na diagnostiku a optimalizáciu terapie srdcových arytmií
Program: VEGA
Duration: 1.1.2025 – 31.12.2028
Project leader: Ing. Švehlíková Jana, PhD.
Annotation: In the proposed project, we plan to link multi-lead ECG measurements on the chest with a personalized model of the heart and chest of the measured patient obtained from a CT scan. We intend to implement the physiological properties of healthy myocardium into the heart chamber model, as well as some pathological morphological and structural changes, such as left ventricular hypertrophy or left bundle branch block in heart failure. Using simulations of activation propagation in the heart chambers, we will study changes in ECG signals in the above diagnoses, as well as the consequences of different settings of supportive stimulation in resynchronization therapy for heart failure. We will implement advanced methods of signal processing and calculation of selected characteristics in quasi-real time into a new multi-lead ECG measurement system with wireless data transmission to a control computer.
ReAcMap – Assessment of restitution of normal ventricular activation by ECG mapping
Vyhodnotenie reštitúcie normálnej komorovej aktivácie pomocou EKG mapovania
Program: SRDA
Duration: 1.9.2025 – 31.8.2028
Project leader: Ing. Švehlíková Jana, PhD.
Annotation: The project intends to optimize and personalize cardiac resynchronization therapy (CRT) for patients with heart failure. This effective, nonpharmacological, pacing-based treatment aims to restore interventricular resynchronization of ventricular activation by pacing both ventricles with an expected subsequent increase in cardiac output. However, about 30-40% of the patients do not benefit from the therapy and are designed as “non-responders”. To improve the efficacy of ventricular resynchronization, conduction system pacing (CSP) was recently introduced into clinical practice, which replaces biventricular stimulation with direct stimulation of the conduction system. However, CSP to achieve a narrow QRS complex is not feasible in up to 15% of patients for multiple anatomical, pathological, and technical reasons. Therefore, an optimal individualized strategy to achieve effective ventricular resynchronization is an unmet need in electrical therapies in heart failure patients. The proposed research project is methodologically based on noninvasive body surface potential ECG measurements of patients with heart failure indicated for a CRT/CSP device implantation. From the measured data, conducted using a dedicated in-house measuring device, the new parameters for the evaluation of the dynamics of the ventricular activation will be derived to set the proper programming stimulation of the device. A possible reduction of the number of ECG electrodes from the currently used 128 will also be studied to facilitate the routine clinical feasibility of the recording system. The simulations of the failing heart will be performed to understand better the processes that are undergoing in the ventricles. The area of the starting spontaneous ventricular activity will be assessed by solving the inverse problem of electrocardiography using a personalized heart-torso model obtained from the CT scan. The dedicated measuring system will implement a GUI to apply the suggested methods easily.