Fast 3D magnetic field mapping using MRSI with circular sampling for 31P applications

Investigators: Ladislav Valkovič, Pavol Szomolányi

Quantifying the concentration of energy metabolites requires accurate measurement of the magnetic field (B1), especially at 7T where the excitation coils face large field inhomogeneities. Measuring the B1 field using standard signal sampling is relatively time-consuming. It takes about 40 minutes to cover the entire heart, which is too long for clinical use. Therefore, we tested our fast sampling technique using a circular trajectory to measure the B1 field. This reduced the field mapping measurement time to 5 minutes. First, we compared the new fast maps obtained in this way with the original slow sampling in skeletal muscle, and then applied this technique to measurements on the heart. This technique will be of great importance not only for quantification but also for mapping the speed of chemical reactions in the heart, which can be incorporated into clinical studies, such as our latest study using MitoQ antioxidants in patients with dilated cardiomyopathy, where we compared only the PCr/ATP ratio.

Projects: APVV-24-0504

Fig. 1: Map of the excitation angle, measured using standard slow signal sampling (one slice per 13 minutes) in panel a), and using fast sampling with a circular trajectory (3D volume per 5 minutes) in panel b).

Foreign partner: Oxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital, Headington, Oxford, UK, scientific cooperation agreement signed on May 7, 2024.

Publications:

• VALKOVIČ, Ladislav– MÓZES, F.E. – LYU, Y. – KARKOURI, J. – RODGERS, C.T. – NIESS, F. – BOGNER, W. – SZOMOLÁNYI, Pavol. Fast 3D ³¹P B₁⁺ mapping using concentric ring trajectory MRSI at 7 T. In Proceedings of the 15th International Conference on Measurement. – Bratislava : Institute of Measurement Science, SAS, 2025, p. 180-183. ISBN 978-80-69159-01-3
• HALLIDAY, B.P. – OWEN, R. – RAGAVAN, A. – SMITH, K.L. – STATTON, B. – BERRY, A. – KASIAKOGIAS, A. – TSOUMANI, Z. – SHANMUGNATHAN, M. – DUNGU, J.N. – DE MARVAO, A. – TAYAL, U. – WARE, J.S. – O’REGAN, D.P. – PENNELL, D.J. –  CLELAND, J.G.F. – PRASAD, S.K. – GREGSON, J. – MURPHY, M.P. – RIDER, O. – VALKOVIČ, Ladislav. A double-blind, randomised placebo-controlled trial examining the effect of MitoQ on myocardial energetics in patients with dilated cardiomyopathy. In European Heart Journal – Cardiovascular Imaging, 2025. ISSN 2047-2404. (6.6 – IF2024) Q1, D1
• GODLEWSKA, B.R. – SYLVESTER, A.L. – EMIR, U.E. – SHARPLEY, A.L. – CLARKE, W.T. – WILLIAMS, S.R. – GONÇALVES, A.J. – RAMAN, B. – VALKOVIČ, Ladislav– COWEN, P.J. Brain and muscle chemistry in myalgic encephalitis/chronic fatigue syndrome (ME/CFS) and long COVID: A 7T magnetic resonance spectroscopy study. In Molecular Psychiatry, 2025, vol. 30, p. 5215-5226. ISSN 1359-4184. (10.1 – IF2024) Q1, D1
• DEVESA, A. – DELGADO, V. – VALKOVIČ, Ladislav– LIMA, J.A.C. – NAGEL, E. – IBANEZ, B. – RAMAN, B. Multiorgan imaging for interorgan crosstalk in cardiometabolic diseases. In Circulation Research, 2025, vol. 136, no. 11, p. 1454-1475.  ISSN 0009-7330. (16.2 – IF2024) Q1, D1
• THIRUNAVUKARASU, S. – ANSARI, F. – KOTHA, S. – GIANNOUDI, M. – PROCTER, H. – CASH, L. – CHOWDHARY, A. – JEX, N. – SHIWANI, H. – FORBES, K. – VALKOVIČ, Ladislav– KELLMAN, P. – PLEIN, S. – GREENWOOD, J.P. – EVERETT, T. – SCOTT, E.M. – LEVELT, E. Cardiac structural, functional and energetic assessments during and after pregnancy in women with gestational diabetes mellitus, preeclampsia and healthy pregnancy. In American Journal of Obstetrics and Gynecology, 2025, vol. 232, no. 6, p. 565.e1-565.e16. ISSN 0002-9378. (8.4 – IF2024) Q1, D1