Projects

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COMULIS – Correlated Multimodal Imaging in Life Sciences
Korelované multimodálne zobrazovanie vo vedách o živej prírode
Program: COST
Project ID: CA 17121
Duration: 12.10.2018 – 11.10.2022
Project leader: RNDr. Hain Miroslav PhD.
Annotation: The network aims at fueling urgently needed collaborations in the field of correlated multimodal imaging (CMI), promoting and disseminating its benefits through showcase pipelines, and paving the way for its technological advancement and implementation as a versatile tool in biological and preclinical research. CMI combines two or more imaging modalities to gather information about the same specimen. It creates a composite view of the sample with multidimensional information about its macro-, meso- and microscopic structure, dynamics, function and chemical composition. Since no single imaging technique can reveal all these details, CMI is the only way to understand biomedical processes and diseases mechanistically and holistically. CMI relies on the joint multidisciplinary expertise from biologists, physicists, chemists, clinicians and computer scientists, and depends on coordinated activities and knowledge transfer between academia and industry, and instrument developers and users. Due to its inherently multidisciplinary and cross-functional nature, an interdisciplinary network such as this Action is indispensable for the success of CMI. Nevertheless, there is currently no European network in the field. Existing scattered efforts focus on correlated light and electron microscopy or (pre)clinical hybrid imaging. This Action will consolidate these efforts, establish commonly-accepted protocols and quality standards for existing CMI approaches, identify and showcase novel CMI pipelines, bridge the gap between preclinical and biological imaging, and foster correlation software through networking, workshops and open databases. The network will raise awareness for CMI, train researchers in multimodal approaches, and work towards a scientific mindset that is enthusiastic about interdisciplinary imaging approaches in life sciences.
Project webpage: https://e-services.cost.eu/action/CA17121
Understanding and modeling compound climate and weather events
Porozumenie a modelovanie združených klimatických a meteorologických javov
Program: COST
Project ID: CA17109
Duration: 14.9.2018 – 13.9.2022
Project leader: Mgr. Chvosteková Martina PhD.
Annotation: Hazards such as floods, wildfires, heatwaves, and droughts usually result from a combination of interacting physical processes that occur across multiple spatial and temporal scales. The combination of physical processes leading to an impact is referred to as a Compound Event. Examples of high-impact Compound Events include (i) droughts, heatwaves, wildfire and/or air pollution and their interactions involving a complex interplay between temperature, humidity and precipitation; (ii) extreme precipitation, river discharge and storm surge interactions, combining coastal storm processes with fluvial/pluvial and ocean dynamics; (iii) storms including clustering of major events leading to spatial and/or temporal dependence.Climate change alters many of these processes and their interaction, making projections of future hazards based on single driver analyses difficult. Impact studies considering only one driver usually fail to assess the extent of the impacts of Compound Events. It is thus not clear whether climate models can capture major changes in risk associated with Compound Events. Existing modelling approaches used to assess risk may therefore lead to serious mal-adaptation.DAMOCLES will (a) identify key process and variable combinations underpinning Compound Events; (b) describe the available statistical methods for modelling dependence in time, space, and between multiple variables; (c) identify data requirements needed to document, understand, and simulate Compound Events, and (d) propose an analysis framework to improve the assessment of Compound Events. DAMOCLES brings together climate scientists, impact modellers, statisticians, and stakeholders to better understand, describe and project Compound Events, and foresees a major breakthrough in future risk assessments.
Project webpage: https://www.cost.eu/actions/CA17109
European network for advancing Electromagnetic hyperthermic medical technologies.
Európska sieť pre pokrok v elektromagnetických hypertermických medicínskych technológiách
Program: COST
Project ID: COST action CA17115
Duration: 4.9.2018 – 3.9.2022
Project leader: Mgr. Teplan Michal PhD.
Annotation: Electromagnetic (EM) hyperthermic technologies hold great potential in the treatment of diseases, especially for cancers that are resistant to standard regimens. These technologies modify tissue temperature: hyperthermia heats the diseased tissue to make it susceptible to treatments, and ablation heats the tissue until it is destroyed. Hyperthermia is particularly effective in treatment of cervical and breast cancer, head and neck cancers, sarcoma in adults, and germ cell tumours in children; while radiofrequency and microwave ablation offer promise for treating liver, kidney, and lung cancers.Overall, these techniques have shown significant potential and there is substantial opportunity to solidify their use clinically and to apply them to a wider range of medical conditions. However, underpinning the development of these techniques is the need for accurate knowledge of the dielectric and thermal properties of tissues, which provide the foundation for these technologies and de-risk the technical challenge before commercialization. Furthermore, contributing to the stagnant market of EM hyperthermic medical devices is the fact that, often researchers working on the development of medical technologies are not fully aware of, and not trained to address, the clinical and commercialisation challenges facing novel medical devices. To address these challenges, the MyWAVE Action takes a holistic approach by bringing together key players in the field of dielectric spectroscopy, translational research, and medical professionals. Conjoining these varied communities into one collaborative network is critical to advance the design, development, and commercialisation of EM hyperthermic technologies, so that they can reach patients faster and improve treatment outcomes.
Project webpage: www.cost.eu/actions/CA17115
MULTI-FORESEE – MULTI-modal Imaging of FOREnsic SciEnce Evidence (MULTI-FORESEE) – tools for Forensic Science
Multimodálne zobrazovanie dôkazov forenznej vedy – nástroje pre forenznú vedu
Program: COST
Project ID: CA16101
Duration: 1.8.2018 – 1.3.2021
Project leader: RNDr. Hain Miroslav PhD.
Annotation: The main objective is to promote innovative, multi-informative, operationally deployable and commercially exploitable imaging solutions/technology to analyse forensic evidence. Forensic evidence includes, but not limited to, fingermarks, hair, paint, biofluids, digital evidence, fibers, documents and living individuals. Imaging technologies include optical, mass spectrometric, spectroscopic, chemical, physical and digital forensic techniques complemented by expertise in IT solutions and computational modelling. Imaging technologies enable multiple physical and chemical information to be captured in one analysis, from one \’specimen\’, with information being more easily conveyed and understood for a more rapid exploitation. The ‘enhanced’ value of the evidence gathered will be conducive to much more informed investigations and judicial decisions thus contributing to both savings to the public purse and to a speedier and stronger criminal justice system. Lack of knowledge sharing, standardised protocols and communication between Academia, End Users and industry has been a barrier to translational science in this field; the Action will use the unique networking and capacity-building capabilities provided by the COST framework to bring together their knowledge and expertise; this is paramount to engage in a synergistic approach to boost imaging technological developments, allowing scientifically sound, highly reliable and multi-informative intelligence to be provided to investigators, prosecutors and defence. COST support is crucial to conquer the challenge on short term basis and to provide a legacy to Europe to advance knowledge for the deployment of cutting edge, innovative and implementable imaging forensic science.
Project webpage: https://www.cost.eu/actions/CA16101
KZM – Comparative imaging methods based on magnetic resonance
Komparatívne zobrazovacie metódy na báze magnetickej rezonancie
Program: Bilateral – other
Project ID: ASC-2020
Duration: 1.3.2017 – 31.12.2020
Project leader: Prof. Ing. Frollo Ivan DrSc.
Annotation: Research of comparative imaging methods based on magnetic resonance for diagnostics of neurological and musculoskeletal diseases.Imaging of micro- and nanostructures based on magnetic resonance for biomedical and material research.Mutual visits of scientists and PhD students enabling them to perform imaging experiments on MRI instruments in the laboratories of partners in the appropriate time limits.
Novel integrated approaches for research of biomedical effects of pulsed electric fields
Nové integrované prístupy pre výskum biomedicínskych účinkov pulzných elektrických polí
Program: Inter-academic agreement
Project ID: SAV-18-11
Duration: 1.1.2018 – 31.12.2020
Project leader: Mgr. Teplan Michal PhD.
Annotation: Intense pulsed electric fields have already use and great further potential for novel applications in biomedicine and food industry. However, the mechanistic details of the action of pulsed electric fields on the plasma membrane and especially on the intracellular level are still not clear. This project is focused on theoretical and experimental characterization of the effects of pulsed electric fields from the level of subcellular biomolecular structures to a cellular level. We aim to develop and employ approaches based on impedance spectroscopy and chemiluminescence detection which will enable us to explore the most prominent bioeffects of pulsed electric fields in a real-time, non-invasive and label-free manner. The major technological novelty will be in the integration of these monitoring tools to an automatic programmable experimental platform.The results of the project will provide new methods in the research of effects of electromagnetic fields on living cells and will bring future medical applications closer to reality.
Preparation and study of the precursor properties for development of nanomaterials based on metal oxides
Príprava a štúdium vlastností prekurzorov pre vývoj nanomateriálov na báze oxidov kovov
Program: Bilateral – other
Project ID: AI5/TT/1170
Duration: 1.7.2016 – 31.12.2020
Project leader: RNDr. Cigáň Alexander CSc.
Annotation: The subject of common interest include the following main areas:1. Technology of HTc superconducting oxides based on Yttrium, Bismuth, Thalium and Mercury – bulks, tapes and thin films. 2. Investigation of the physical properties of these materials with the help of magnetization measurements. 3. Common experiments performed with LTc SQUID gradiometric system (at IMS SAS, Bratislava) and LakeShore susceptometer (at the Department of Inorganic and Physical Chemistry, Ghent). 4. Publication of results on cooperative scientific activities.
DIMPP – Development of innovative methods for primary metrology torque forces by force effects of the conventional standards
Vývoj inovatívnych metód pre primárnu metrológiu momentu sily aplikáciou silových účinkov konvenčnej etalonáže
Program: SRDA
Project ID: APVV-18-0066
Duration: 1.7.2019 – 30.6.2022
Project leader: Doc. RNDr. Witkovský Viktor CSc.
Annotation: Torque is one of the main indicators for testing, respectively. testing a wide range of rotating machines and equipment. Measurements in the area over the last decades show a growing trend in terms of both quantity and quality requirements. This factor is also contributing to the growth of the automotive industry in Slovakia. Measuring momentum is inherently related to metrological continuity and the development of both industrial and secondary metrology. At present, however, the SR does not have a laboratory which, with its technical equipment and metrological quality, represents the highest level of primary metrology. The momentary force calibration laboratories in the SR are forced to look for sources of metrological continuity abroad. The aim of the project is therefore to lay the foundations of primary momentum metrology.
Analysis of multivariate time series and its application to research of functional connectivity in the brain
Analýza viacrozmerných časových radov a jej aplikácie na výskum funkčných prepojení v mozgu
Program: VEGA
Project ID: 2/0081/19
Duration: 1.1.2019 – 31.12.2021
Project leader: RNDr. Krakovská Anna CSc.
Annotation: The project is focused on the analysis of complex experimental time series. Applications will mainly concern the multi-channel electroencephalographic (EEG) signals measured from the human brain. We will be interested in functional connectivity between brain regions. The time series will not be examined in isolation, but as one of the manifestations of a complex system or subsystem. The analysis of simultaneously measured signals should help trace areas in the brain that are relatively independent or synchronized or causally affected by each other. Our focus will be on brain functional state changes during experiments focused on monitoring selected cognitive processes. We will also deal with the hypothesis of self-organized, scale-free, fractal processes in brain functioning. In terms of methodology, we would like to contribute to the development of multivariate causal methods, algorithms for multidimensional statistical analysis, and machine learning methods for the processing and analysis of EEG signals.
Measurement and modeling of the cardiac electrical field for noninvasive identification and interpretation of structural changes of the ventricular myocardium leading to ventricular arrhythmias
Meranie a modelovanie elektrického poľa srdca na neinvazívnu identifikáciu a interpretáciu štrukturálnych zmien komorového myokardu vedúcich k ventrikulárnym arytmiám
Program: VEGA
Project ID: 2/0125/19
Duration: 1.1.2019 – 31.12.2021
Project leader: Ing. Švehlíková Jana PhD.
Annotation: The project is focused on the research of the measuring methods and processing of the electrical manifestation of the heart activity with the aim to diagnose myocardial structural changes or origins of the ventricular arrhythmias noninvasively. The main goal is a robust inverse solution for noninvasive localization and characterization of the origin of premature ventricular complexes and obtaining relevant medical information for radiofrequency ablation therapy. One part of the solution will be the methods for pathological heart activation modeling and computation of the potentials on the individual torso surface. The selection of an electrical generator model, heart activation process, and electrical parameters of the anisotropic torso allow optimization of the forward and inverse solution. To achieve the goals, advanced methods for ECG signals variability analysis as well as parallel computational methods will be proposed. A concept of ECG measuring system with a wireless data transfer will be developed.
Origin of amniotes: identification of key structures of the most-basal amniotes using computed microtomography
Pôvod amniótov: identifikácia kľúčových štruktúr najbazálnejších amniótov využitím počítačovej mikrotomografie
Program: VEGA
Project ID: 1/0228/19
Duration: 1.1.2019 – 31.12.2021
Project leader: RNDr. Hain Miroslav PhD.
Annotation: Our knowledge of the skeletal structures, on the basis of which it is possible to identify the most-basal amniotes,will be focused on the study: 1) of stem amniotes having an amphibian reproductive strategy, and 2) of the basalamniotes with the terrestrial reproductive strategy. Besides this, the investigation will be focused on theParmo-Carboniferous group Diadectomorpha, the members of which play a key role as for the origin of amniotes.The first aim of the project is the knowledge of morphological transformations of the neurocranial structuresduring the evolutionary transition of tetrapods with amphibian reproductive strategy (Anamnia, the reproductiondepending on external water) to tetrapods with reproduction not more depending on external water (Amniota, theyleg the amniotic eggs on the land).The second aim is to evaluate all gained morphological data in the phylogenetic analysis to resolve therelationships of the investigated taxa at the transition stem amniotes – basal crown amniotes.
Development of experimental platform and analytical tools for measurement of low frequency electromagnetic field effects on biological systems
Vývoj experimentálnej platformy a nástrojov analýzy na meranie účinkov nízkofrekvenčných elektromagnetických polí na biologické systémy
Program: VEGA
Project ID: 2/0157/19
Duration: 1.1.2019 – 31.12.2021
Project leader: Mgr. Teplan Michal PhD.
Annotation: The aim of the project is to develop measurement methods and analysis tools for identification of the effects of weak low frequency (LF) electromagnetic (EM) fields on selected biological systems. The main objective is the development of an automated experimental platform comprising multiple measurement stations, allowing monitoring and subsequent characterization of cell cultures. Main detection approaches include methods of impedance spectroscopy, turbidimetry, and optical microscopy. A complex hardware-software system will allow efficient scanning of frequencies and amplitudes of EM fields in order to identify parameters that lead to a specific response in the examined biosystems. Morphology and cell kinetics will be investigated by computer image analysis obtained from video-microscopy. The results will be analyzed for their possible applications in emergent problems of contemporary society.
ECoReMiR – Enhancing cognition and motor rehabilitation using mixed reality
Vylepšovanie kognície a motorickej rehabilitácie s využitím zmiešanej reality
Program: SRDA
Project ID: APVV-16-0202
Duration: 1.7.2017 – 30.6.2021
Project leader: Ing. Mgr. Rosipal Roman PhD.
Annotation: Technological advancements based on mixed reality (MR) offer various challenges for research and medicaltreatment. The project focuses on two objectives related to healthy subjects and hemiparetic patients after stroke. First, we will test the hypothesis whether cognitive training using appropriately designed MR environment will enhance perceptual and cognitive performance in healthy subjects. This will be tested by computerized psychological experiments as well as by measuring event-related potentials or ERPs. Second, we will test the hypothesis whether experience with training in MR (in combination with motor-imagery based brain-computer interface developed by us) will enhance oscillatory sensory-motor rhythms. This will be tested by measuring subject’s EEG activity before and after each training session, clinical testing, as well as by the questionnaires aiming to learn about human factors including mental fatigue, motivation, irritation or sleepiness due to training. In both objectives, we will design and implement a set of testing procedures, carry out a battery of dedicatedexperiments, and critically evaluate the results with the goal to validate MR designs.
RIDD – Research of magnetic forms of iron in development of cardiovascular diseases and behavioural disorders
Výskum magnetických foriem železa v rozvoji kardiovaskulárnych chorôb a porúch správania
Program: SRDA
Project ID: APVV-16-0263
Duration: 1.7.2017 – 30.6.2021
Project leader: Ing. Maňka Ján CSc.
Annotation: This project proposal is focused on the investigation of the role of iron in development of cardiovascular and behavioural disorders, prevalence of which is increasing during aging. The aim of this project is to investigate the impact of aging on the metabolism of biogenic iron and its magnetic properties in association with metabolic and functional alterations in the cardiovascular system and brain in rats with various genetic predispositions to hypertension. We will determine the molecular biological changes on the level of gene expression, their encoded proteins and the activities of the enzymes involved in the endogenous antioxidant protection, the regulation of nitric oxide production and cell death due to ferroptosis in course of aging. We will also investigate the impact of exogenously administered iron in the form of the biocompatible ultrasmall superparamagnetic iron oxide nanoparticles (USPIONs) on blood pressure regulation and function of the heart and blood vessels in conditions of normotension, chronically increased blood pressure and acute stress (i.e. acutely elevated blood pressure). Results achieved in this project will contribute to better understanding of the effects of the altered iron metabolism, magnetic forms of bodily iron, as well as iron in the form of USPIONs, on the cardiovascular and central nervous systems and to prevention of cardiovascular risk resulting from the use of USPIONs in targeted drug delivery or as the contrast materials for new imaging methods in medicine.
Project webpage: http://www.bionanoiron.sav.sk/
Morfology of fossil lizards using micro-computed tomography, their phylogeny, paleobiogeography – migrations and faunal changes during the climatic changes of Cenozoic
Morfológia fosílnych jašterov s použitím zobrazovacích techník počítačovej mikrotomografie, ich fylogenetické vzťahy, paleobiogeografia – migrácie a zmeny spoločenstiev odrážajuce postupné klimatické zmeny kenozoika
Program: VEGA
Project ID: 1/0209/18
Duration: 1.1.2018 – 31.12.2020
Project leader: RNDr. Hain Miroslav PhD.
Annotation: Project deals with new, in most cases complete finds of lizards from the Cenozoic, which is a period characterized by marked global climate changes. The aim is the anatomical research of fossil and modern animals using micro-CT.
New statistical methods for special families of probability distributions and their applications
Nové štatistické metódy pre špeciálne triedy rozdelení pravdepodobnosti a ich aplikácie
Program: VEGA
Project ID: 2/0054/18
Duration: 1.1.2018 – 31.12.2020
Project leader: Doc. RNDr. Witkovský Viktor CSc.
Annotation: The project analyzes special classes of probability distributions. New statistical methods for distributions from these classes are suggested and theoretically characterized, namely, parameter estimations, goodness of fit tests, and parametric and non-parametric statistical inference. This statistical apparatus is then applied to specific problems in metrology, insurance and financial mathematics, linguistics and demography. As a part of the project, computational methods and algorithms are constructed for these statistical procedures.
Effect of ultrasmall superparamagnetic iron oxide nanoparticles on the cardiovascular system of rats with high blood pressure
Vplyv ultra malých superparamagnetických nanočastíc železa na kardiovaskulárny systém potkana v podmienkach vysokého krvného tlaku
Program: VEGA
Project ID: 2/0160/17
Duration: 1.1.2017 – 31.12.2020
Project leader: Ing. Maňka Ján CSc.
Annotation: This project will investigate the effect of ultrasmall superparamagnetic iron oxide nanoparticles (USPIONs) on function and structure of the arterial wall and the heart in rats with high blood pressure. We will investigate if acute stress and chronic high blood pressure can facilitate the USPIONs uptake in the arterial wall and heart, to modify cardiovascular function, including blood pressure regulation and to induce metabolic disorders, oxidative damage and alterations of the Fe2+/Fe3+ ratio in the heart and vasculature. We will investigate if L-type of voltage-dependent calcium channels is involved in iron uptake after USPIONs treatment. Results achieved in this project will contribute to better understanding of USPIONs effects on the cardiovascular system in conditions of acute stress and high blood pressure as well as on prevention of cardiovascular risk resulting from the use of USPIONs in targeted drug delivery.
Research on possibilities and development of SQUID magnetometry for selected applications in biomedicine and material research
Výskum možností a rozvoj SQUID magnetometrie pre vybrané aplikácie v biomedicíne a materiálovom výskume
Program: VEGA
Project ID: 2/0164/17
Duration: 1.1.2017 – 31.12.2020
Project leader: Ing. Maňka Ján CSc.
Annotation: Project has an interdisciplinary character.The aim is to show the possibilities of use of the SQUID magnetometry in study of the actual processes in medicine, biology and material research: -in analysis of the properties and magnetic characterization of the nanoparticles and nanoliquids, especially ultra-small superparamagnetic nanoparticles based on iron oxides (USPIONs) -in investigation of the influence of the USPIONs on the function and structure of the blood vessels and heart, on development of the oxidative damage and in study of processes of the USPIONs transport through cell membranes, blood vessels and organs of rats with normal and high blood pressure -in development of the procedures and methods of quantification of the magnetic substances content in the human and animal cell cultures and organs – in study and development of the aluminate glasses with photoluminescence properties – in development of new 2D materials, MXenes, exfoliated transition metal carbides and carbonitrides
METSTAT – Advanced statistical and computational methods for measurement and metrology
Pokročilé štatistické a výpočtové metódy pre meranie a metrológiu
Program: SRDA
Project ID: APVV-15-0295
Duration: 1.7.2016 – 30.6.2020
Project leader: Doc. RNDr. Witkovský Viktor CSc.
Annotation: The aim of the project is to develop mathematical and statistical methods and algorithms for evaluation of the measurement results with emphasis on the development of models and methods for multivariate calibration of measuring devices and methods and algorithms for determining the uncertainties in measurement by deriving the exact resp. approximate probability distributions of the measurement results. Research will focus primarily onthe following areas: • Theoretical research on mathematical and statistical models and methods for multivariate calibration;• Development of calibration theory of the sensors and transducers, uncertainty determination in calibration ofsensor under the normally distributed measurement errors as well as under the alternative probability distributions of measurement errors, development of procedures for calibration and measurement evaluation useful in laboratory work, evaluation of sensor calibration in the thermal and mechanical quantities withcontinuous scale (pressure transmitter, thermocouple temperature sensors , resistance thermometers, etc.), and determination of the calibration values of the physico-chemical parameters by using the certified reference materials; • Development of methods and algorithms to determine the exact resp. approximate probability distribution of measurement results by combining and inverting the characteristic functions of the probability distributions of theinput variables and characterizing uncertainty in metrology.The application of the mathematical, statistical, and computational methods for the measurement science and metrology is high on the agenda, with a significant impact on the international scientific as well as industrial cooperation and economic growth in developed countries. It is in good agreement with the intentions of the strategy for research and development, approved by the Slovak government (SK RIS3).
Measuring and imaging methods based on magnetic resonance for material and biomedical research
Meracie a zobrazovacie metódy na báze magnetickej rezonancie pre materiálový a biomedicínsky výskum
Program: VEGA
Project ID: 2/0001/17
Duration: 1.1.2017 – 31.12.2019
Project leader: Ing. Andris Peter PhD.
Annotation: Measurement, imaging and mapping of specific physical quantities, organic and synthetic materials and objects in the field of development of material a biomedical research. Basic research of selected imaging method based on NMR. The object of the research will be methods of measurement and mapping of specific properties of physical quantities and chemical composition of organic and synthetic materials and objects. Research of soft-magentic nanoliquids properties as a part of contrast materials, thin magnetic layer. Study and selection of appropriate imaging method with orientation on biological and non-biological materials at magnetic fields 0.1 T, 0.2 T, 3.0 T, 4.7 and 7.0 Tesla.Comparative imaging methods, detection of the iron in organism, magnetic properties of iron complexes.Research of relaxation mechanism of influencing of biogenic iron complexes on the water proton using magnetic resonance imaging. Relaxation model as a basis for quantitatively imaging of biological iron complexes.