Projects

International

Porozumenie a modelovanie združených klimatických a meteorologických javov
Understanding and modeling compound climate and weather events
Program: COST
Project leader: Mgr. Chvosteková Martina PhD.
Annotation: Hazards such as floods, wildfires, heatwaves, and droughts usually result from a combination of interacting physical processes that occur across multiple spatial and temporal scales. The combination of physical processes leading to an impact is referred to as a Compound Event. Examples of high-impact Compound Events include (i) droughts, heatwaves, wildfire and/or air pollution and their interactions involving a complex interplay between temperature, humidity and precipitation; (ii) extreme precipitation, river discharge and storm surge interactions, combining coastal storm processes with fluvial/pluvial and ocean dynamics; (iii) storms including clustering of major events leading to spatial and/or temporal dependence.Climate change alters many of these processes and their interaction, making projections of future hazards based on single driver analyses difficult. Impact studies considering only one driver usually fail to assess the extent of the impacts of Compound Events. It is thus not clear whether climate models can capture major changes in risk associated with Compound Events. Existing modelling approaches used to assess risk may therefore lead to serious mal-adaptation.DAMOCLES will (a) identify key process and variable combinations underpinning Compound Events; (b) describe the available statistical methods for modelling dependence in time, space, and between multiple variables; (c) identify data requirements needed to document, understand, and simulate Compound Events, and (d) propose an analysis framework to improve the assessment of Compound Events. DAMOCLES brings together climate scientists, impact modellers, statisticians, and stakeholders to better understand, describe and project Compound Events, and foresees a major breakthrough in future risk assessments.
Duration: 14.9.2018 – 13.9.2022
Európska sieť pre pokrok v elektromagnetických hypertermických medicínskych technológiách
European network for advancing Electromagnetic hyperthermic medical technologies.
Program: COST
Project leader: Mgr. Teplan Michal PhD.
Annotation: Electromagnetic (EM) hyperthermic technologies hold great potential in the treatment of diseases, especially for cancers that are resistant to standard regimens. These technologies modify tissue temperature: hyperthermia heats the diseased tissue to make it susceptible to treatments, and ablation heats the tissue until it is destroyed. Hyperthermia is particularly effective in treatment of cervical and breast cancer, head and neck cancers, sarcoma in adults, and germ cell tumours in children; while radiofrequency and microwave ablation offer promise for treating liver, kidney, and lung cancers.Overall, these techniques have shown significant potential and there is substantial opportunity to solidify their use clinically and to apply them to a wider range of medical conditions. However, underpinning the development of these techniques is the need for accurate knowledge of the dielectric and thermal properties of tissues, which provide the foundation for these technologies and de-risk the technical challenge before commercialization. Furthermore, contributing to the stagnant market of EM hyperthermic medical devices is the fact that, often researchers working on the development of medical technologies are not fully aware of, and not trained to address, the clinical and commercialisation challenges facing novel medical devices. To address these challenges, the MyWAVE Action takes a holistic approach by bringing together key players in the field of dielectric spectroscopy, translational research, and medical professionals. Conjoining these varied communities into one collaborative network is critical to advance the design, development, and commercialisation of EM hyperthermic technologies, so that they can reach patients faster and improve treatment outcomes.
Project webpage: www.cost.eu/actions/CA17115
Duration: 4.9.2018 – 3.9.2022
MULTI-FORESEE – Multimodálne zobrazovanie dôkazov forenznej vedy – nástroje pre forenznú vedu
MULTI-modal Imaging of FOREnsic SciEnce Evidence (MULTI-FORESEE) – tools for Forensic Science
Program: COST
Project leader: RNDr. Hain Miroslav PhD.
Annotation: The main objective is to promote innovative, multi-informative, operationally deployable and commercially exploitable imaging solutions/technology to analyse forensic evidence. Forensic evidence includes, but not limited to, fingermarks, hair, paint, biofluids, digital evidence, fibers, documents and living individuals. Imaging technologies include optical, mass spectrometric, spectroscopic, chemical, physical and digital forensic techniques complemented by expertise in IT solutions and computational modelling. Imaging technologies enable multiple physical and chemical information to be captured in one analysis, from one \’specimen\’, with information being more easily conveyed and understood for a more rapid exploitation. The ‘enhanced’ value of the evidence gathered will be conducive to much more informed investigations and judicial decisions thus contributing to both savings to the public purse and to a speedier and stronger criminal justice system. Lack of knowledge sharing, standardised protocols and communication between Academia, End Users and industry has been a barrier to translational science in this field; the Action will use the unique networking and capacity-building capabilities provided by the COST framework to bring together their knowledge and expertise; this is paramount to engage in a synergistic approach to boost imaging technological developments, allowing scientifically sound, highly reliable and multi-informative intelligence to be provided to investigators, prosecutors and defence. COST support is crucial to conquer the challenge on short term basis and to provide a legacy to Europe to advance knowledge for the deployment of cutting edge, innovative and implementable imaging forensic science.
Project webpage: https://www.cost.eu/actions/CA16101
Duration: 1.8.2018 – 1.3.2021
KZM – Komparatívne zobrazovacie metódy na báze magnetickej rezonancie
Comparative imaging methods based on magnetic resonance
Program: Bilateral – other
Project leader: Prof. Ing. Frollo Ivan DrSc.
Annotation: Research of comparative imaging methods based on magnetic resonance for diagnostics of neurological and musculoskeletal diseases.Imaging of micro- and nanostructures based on magnetic resonance for biomedical and material research.Mutual visits of scientists and PhD students enabling them to perform imaging experiments on MRI instruments in the laboratories of partners in the appropriate time limits.
Duration: 1.3.2017 – 31.12.2020
Nové integrované prístupy pre výskum biomedicínskych účinkov pulzných elektrických polí
Novel integrated approaches for research of biomedical effects of pulsed electric fields
Program: Inter-academic agreement
Project leader: Mgr. Teplan Michal PhD.
Annotation: Intense pulsed electric fields have already use and great further potential for novel applications in biomedicine and food industry. However, the mechanistic details of the action of pulsed electric fields on the plasma membrane and especially on the intracellular level are still not clear. This project is focused on theoretical and experimental characterization of the effects of pulsed electric fields from the level of subcellular biomolecular structures to a cellular level. We aim to develop and employ approaches based on impedance spectroscopy and chemiluminescence detection which will enable us to explore the most prominent bioeffects of pulsed electric fields in a real-time, non-invasive and label-free manner. The major technological novelty will be in the integration of these monitoring tools to an automatic programmable experimental platform.The results of the project will provide new methods in the research of effects of electromagnetic fields on living cells and will bring future medical applications closer to reality.
Duration: 1.1.2018 – 31.12.2020
Príprava a štúdium vlastností prekurzorov pre vývoj nanomateriálov na báze oxidov kovov
Preparation and study of the precursor properties for development of nanomaterials based on metal oxides
Program: Bilateral – other
Project leader: RNDr. Cigáň Alexander CSc.
Annotation: The subject of common interest include the following main areas:1.Technology of HTc superconducting oxides based on Yttrium, Bismuth, Thalium and Mercury – bulks, tapes and thin films.2.Investigation of the physical properties of these materials with the help of magnetization measurements.3.Common experiments performed with LTc SQUID gradiometric system (at IMS SAS, Bratislava) and LakeShore susceptometer (at the Department of Inorganic and Physical Chemistry, Ghent).4.Publication of results on cooperative scientific activities.
Duration: 1.7.2016 – 31.12.2020

National

Vývoj experimentálnej platformy a nástrojov analýzy na meranie účinkov nízkofrekvenčných elektromagnetických polí na biologické systémy
Development of experimental platform and analytical tools for measurement of low frequency electromagnetic field effects on biological systems
Program: VEGA
Project leader: Mgr. Teplan Michal PhD.
Annotation: The aim of the project is to develop measurement methods and analysis tools for identification of the effects of weak low frequency (LF) electromagnetic (EM) fields on selected biological systems. The main objective is the development of an automated experimental platform comprising multiple measurement stations, allowing monitoring and subsequent characterization of cell cultures. Main detection approaches include methods ofimpedance spectroscopy, turbidimetry, and optical microscopy. A complex hardware-software system will allow efficient scanning of frequencies and amplitudes of EM fields in order to identify parameters that lead to a specific response in the examined biosystems. Morphology and cell kinetics will be investigated by computer image analysis obtained from video-microscopy. The results will be analyzed for their possible applications in emergent problems of contemporary society.
Duration: 1.1.2019 – 31.12.2021
ECoReMiR – Vylepšovanie kognície a motorickej rehabilitácie s využitím zmiešanej reality
Enhancing cognition and motor rehabilitation using mixed reality
Program: SRDA
Project leader: Rosipal Roman Dr.
Annotation: Technological advancements based on mixed reality (MR) offer various challenges for research and medicaltreatment. The project focuses on two objectives related to healthy subjects and hemiparetic patients afterstroke. First, we will test the hypothesis whether cognitive training using appropriately designed MR environmentwill enhance perceptual and cognitive performance in healthy subjects. This will be tested by computerizedpsychological experiments as well as by measuring event-related potentials or ERPs. Second, we will test thehypothesis whether experience with training in MR (in combination with motor-imagery based brain-computerinterface developed by us) will enhance oscillatory sensory-motor rhythms. This will be tested by measuringsubject’s EEG activity before and after each training session, clinical testing, as well as by the questionnairesaiming to learn about human factors including mental fatigue, motivation, irritation or sleepiness due to training.In both objectives, we will design and implement a set of testing procedures, carry out a battery of dedicatedexperiments, and critically evaluate the results with the goal to validate MR designs.
Duration: 1.7.2017 – 30.6.2021
RIDD – Výskum magnetických foriem železa v rozvoji kardiovaskulárnych chorôb a porúch správania
Research of magnetic forms of iron in development of cardiovascular diseases and behavioural disorders
Program: SRDA
Project leader: Ing. Maňka Ján CSc.
Annotation: This project proposal is focused on the investigation of the role of iron in development of cardiovascular and behavioural disorders, prevalence of which is increasing during aging. The aim of this project is to investigate the impact of aging on the metabolism of biogenic iron and its magnetic properties in association with metabolic and functional alterations in the cardiovascular system and brain in rats with various genetic predispositions to hypertension. We will determine the molecular biological changes on the level of gene expression, their encoded proteins and the activities of the enzymes involved in the endogenous antioxidant protection, the regulation of nitric oxide production and cell death due to ferroptosis in course of aging. We will also investigate the impact of exogenously administered iron in the form of the biocompatible ultrasmall superparamagnetic iron oxide nanoparticles (USPIONs) on blood pressure regulation and function of the heart and blood vessels in conditions of normotension, chronically increased blood pressure and acute stress (i.e. acutely elevated blood pressure). Results achieved in this project will contribute to better understanding of the effects of the altered iron metabolism, magnetic forms of bodily iron, as well as iron in the form of USPIONs, on the cardiovascular and central nervous systems and to prevention of cardiovascular risk resulting from the use of USPIONs in targeted drug delivery or as the contrast materials for new imaging methods in medicine.
Project webpage: http://www.bionanoiron.sav.sk/
Duration: 1.7.2017 – 30.6.2021
Morfológia fosílnych jašterov s použitím zobrazovacích techník počítačovej mikrotomografie, ich fylogenetické vzťahy, paleobiogeografia – migrácie a zmeny spoločenstiev odrážajuce postupné klimatické zmeny kenozoika
Morfology of fossil lizards using micro-computed tomography, their phylogeny, paleobiogeography – migrations and faunal changes during the climatic changes of Cenozoic
Program: VEGA
Project leader: RNDr. Hain Miroslav PhD.
Annotation: Project deals with new, in most cases complete finds of lizards from the Cenozoic, which is a period characterized by marked global climate changes. The aim is the anatomical research of fossil and modern animals using micro-CT.
Duration: 1.1.2018 – 31.12.2020
Nové štatistické metódy pre špeciálne triedy rozdelení pravdepodobnosti a ich aplikácie
New statistical methods for special families of probability distributions and their applications
Program: VEGA
Project leader: Doc. RNDr. Witkovský Viktor CSc.
Annotation: The project analyzes special classes of probability distributions. New statistical methods for distributions from these classes are suggested and theoretically characterized, namely, parameter estimations, goodness of fit tests, and parametric and non-parametric statistical inference. This statistical apparatus is then applied to specific problems in metrology, insurance and financial mathematics, linguistics and demography. As a part of the project, computational methods and algorithms are constructed for these statistical procedures.
Duration: 1.1.2018 – 31.12.2020
Vplyv ultra malých superparamagnetických nanočastíc železa na kardiovaskulárny systém potkana v podmienkach vysokého krvného tlaku
Effect of ultrasmall superparamagnetic iron oxide nanoparticles on the cardiovascular system of rats with high blood pressure
Program: VEGA
Project leader: Ing. Maňka Ján CSc.
Annotation: This project will investigate the effect of ultrasmall superparamagnetic iron oxide nanoparticles (USPIONs) on function and structure of the arterial wall and the heart in rats with high blood pressure. We will investigate if acute stress and chronic high blood pressure can facilitate the USPIONs uptake in the arterial wall and heart, to modify cardiovascular function, including blood pressure regulation and to induce metabolic disorders, oxidative damage and alterations of the Fe2+/Fe3+ ratio in the heart and vasculature. We will investigate if L-type of voltage-dependent calcium channels is involved in iron uptake after USPIONs treatment. Results achieved in this project will contribute to better understanding of USPIONs effects on the cardiovascular system in conditions of acute stress and high blood pressure as well as on prevention of cardiovascular risk resulting from the use of USPIONs in targeted drug delivery.
Duration: 1.1.2017 – 31.12.2020
Výskum možností a rozvoj SQUID magnetometrie pre vybrané aplikácie v biomedicíne a materiálovom výskume
Research on possibilities and development of SQUID magnetometry for selected applications in biomedicine and material research
Program: VEGA
Project leader: Ing. Maňka Ján CSc.
Annotation: Project has an interdisciplinary character.The aim is to show the possibilities of use of the SQUID magnetometry in study of the actual processes in medicine, biology and material research:-in analysis of the properties and magnetic characterization of the nanoparticles and nanoliquids, especially ultra-small superparamagnetic nanoparticles based on iron oxides (USPIONs)-in investigation of the influence of the USPIONs on the function and structure of the blood vessels and heart, on development of the oxidative damage and in study of processes of the USPIONs transport through cell membranes, blood vessels and organs of rats with normal and high blood pressure-in development of the procedures and methods of quantification of the magnetic substances content in the human and animal cell cultures and organs- in study and development of the aluminate glasses with photoluminescence properties- in development of new 2D materials, MXenes, exfoliated transition metal carbides and carbonitrides
Duration: 1.1.2017 – 31.12.2020
METSTAT – Pokročilé štatistické a výpočtové metódy pre meranie a metrológiu
Advanced statistical and computational methods for measurement and metrology
Program: SRDA
Project leader: Doc. RNDr. Witkovský Viktor CSc.
Annotation: The aim of the project is to develop mathematical and statistical methods and algorithms for evaluation of themeasurement results with emphasis on the development of models and methods for multivariate calibration ofmeasuring devices and methods and algorithms for determining the uncertainties in measurement by derivingthe exact resp. approximate probability distributions of the measurement results. Research will focus primarily onthe following areas:• Theoretical research on mathematical and statistical models and methods for multivariate calibration;• Development of calibration theory of the sensors and transducers, uncertainty determination in calibration ofsensor under the normally distributed measurement errors as well as under the alternative probabilitydistributions of measurement errors, development of procedures for calibration and measurement evaluationuseful in laboratory work, evaluation of sensor calibration in the thermal and mechanical quantities withcontinuous scale (pressure transmitter, thermocouple temperature sensors , resistance thermometers, etc.), anddetermination of the calibration values of the physico-chemical parameters by using the certified referencematerials;• Development of methods and algorithms to determine the exact resp. approximate probability distribution ofmeasurement results by combining and inverting the characteristic functions of the probability distributions of theinput variables and characterizing uncertainty in metrology.The application of the mathematical, statistical, and computational methods for the measurement science andmetrology is high on the agenda, with a significant impact on the international scientific as well as industrialcooperation and economic growth in developed countries. It is in good agreement with the intentions of thestrategy for research and development, approved by the Slovak government (SK RIS3).
Duration: 1.7.2016 – 30.6.2020
Meracie a zobrazovacie metódy na báze magnetickej rezonancie pre materiálový a biomedicínsky výskum
Program: VEGA
Project leader: Ing. Andris Peter PhD.
Duration: 1.1.2017 – 31.12.2019
FYZKUL – Fyzikálne nedeštruktívne metódy pre komplexné testovanie a analýzu artefaktov kultúrneho dedičstva.
Physical non-destructive methods for complex testing and analysis of cultural heritage artefacts.
Program: SRDA
Project leader: RNDr. Hain Miroslav PhD.
Annotation: The project deals with the use of the state of the art non-destructive physical methods and devices for analyzing and testing of objects of tangible cultural heritage. Among the comprehensive research methods the X-ray microtomography, X-ray microscopy, scanning electron microscopy, energy-dispersive X-ray spectrometry, ultraviolet fluorescence, infrared reflectography, FTIR spectroscopy, UV, VIS, NIR spectroscopy and active infrared thermography will be used. The project aims to achieve a synergistic effect when information about the artefact derived from different physical measurement methods and subsequently processed and evaluated together will provide qualitatively new comprehensive information on the historical artefact under study.
Duration: 1.7.2015 – 30.6.2019
KompMag – Výskum komparatívnych zobrazovacích metód na báze magnetickej rezonancie na diagnostiku neurologických a muskuloskeletálnych ochorení
Research of comparative imaging methods based on magnetic resonance for diagnostics of neurological and musculoskeletal diseases
Program: SRDA
Project leader: Prof. Ing. Frollo Ivan DrSc.
Annotation: Intense development of the imaging methods based on magnetic resonance using up-to-date technicalequipment – NMR tomographs gives extraordinary chance to the basic research aspects of this scientificorientation.Modern MR open scanners with ability to develop own sequences allow for wide basic research of imaging,measurement and mapping of the specific physical quantities and object for improvement of biomedical andmaterial research with clinical applications.The main goal of this project proposal will be the design of progressive comparative MRI imaging methods usingthe whole range of MRI scanners (0.1, 0.2, 4.7 to 7 Tesla) with special focus on:- theoretical and experimental investigation of scanning approaches measurement and mapping of specificphysical quantities of the organic and synthetic materials,- in-vivo an in-vitro imaging of ferritin at different MR scanners, sequence development, data processing andinvestigation of the ferritin influence on MR image. Imaging of the tissues (brain, liver) and protocolstandardization for imaging of ferritin in the clinical practice,- methods of cartilage and meniscus imaging – the early diagnostics of connective tissue depletion, relaxationtimes mapping for collagen structure assessment,- monitoring of particle deposition as drug carriers to target tissues in the form of superparamagnetic material.The investigation of the possible targeting using gradient magnetic fields,- investigation of artefacts with various sequences, testing of the spectral properties of vibrations and noisegenerated by gradients activity; development, application and testing algorithms for their effect compensation.Additionally, the add on value will be the non-invasive nature of all methods which will be beneficial for earlydiagnostics of pathological processes in medical research and also in clinical practice.
Project webpage: http://www.um.sav.sk/sk/oddelenie-04/vyskum-komparativnych-zobrazovacich-metod-na-baze-magnetickej-rezonancie-na-diagnostiku-neurologickych-a-muskuloskeletalnych-och.html
Duration: 1.7.2016 – 30.6.2019