Principal investigator: Dr. Milan Tyšler

Financial support: requested: capital investments 375 000 SKK, running expences 1 240 000 SKK

The project is aimed at research of methods for noninvasive detection of the functional state of the heart, stomach and brain based on multilead measurements of their external electric fields and on the knowledge of the geometry and electric parameters of the tissues and organs. The research will be focused on inverse methods that enable assessment and display of the status of the organs as distributed proceses described by local transmembrane potentials, activation sequences or surface potentials. To understand the dependences between properties of investigated organs and generated electrical fields, complex models enabling simulation of processes on subcellular, cellular and organ level will be investigated. Suitable combinations of particular models decribed in the literature will be searched to identify diagnostically significant particularities of the organs structure and activity, e.g. behavior of cell membranes, different properties of intra- and extracellular space, inhomogeneity and anisotropy of electrical properties and individual body geometry obtained from MR, CT or USG imaging. Part of the solution will be implementation of selected methods into intelligent measuring systems and their testing in cooperation with Slovak Healthcare University, Institute of Pathological physioloy, school of Medicine, Comenius University and National Institute of Cardiovascular Diseases in Bratislava.