{"id":4039,"date":"2025-12-10T14:26:18","date_gmt":"2025-12-10T13:26:18","guid":{"rendered":"https:\/\/www.um.sav.sk\/en\/?p=4039"},"modified":"2025-12-10T14:26:37","modified_gmt":"2025-12-10T13:26:37","slug":"3-fast-3d-magnetic-field-mapping-using-mrsi-with-circular-sampling-for-31p-applications","status":"publish","type":"post","link":"https:\/\/www.um.sav.sk\/en\/selected-results\/3-fast-3d-magnetic-field-mapping-using-mrsi-with-circular-sampling-for-31p-applications\/","title":{"rendered":"Fast 3D magnetic field mapping using MRSI with circular sampling for 31P applications"},"content":{"rendered":"<p><strong>Investigators:<\/strong> Ladislav Valkovi\u010d, Pavol Szomol\u00e1nyi<\/p>\n<p>Quantifying the concentration of energy metabolites requires accurate measurement of the magnetic field (B1), especially at 7T where the excitation coils face large field inhomogeneities. Measuring the B1 field using standard signal sampling is relatively time-consuming. It takes about 40 minutes to cover the entire heart, which is too long for clinical use. Therefore, we tested our fast sampling technique using a circular trajectory to measure the B1 field. This reduced the field mapping measurement time to 5 minutes. First, we compared the new fast maps obtained in this way with the original slow sampling in skeletal muscle, and then applied this technique to measurements on the heart. This technique will be of great importance not only for quantification but also for mapping the speed of chemical reactions in the heart, which can be incorporated into clinical studies, such as our latest study using MitoQ antioxidants in patients with dilated cardiomyopathy, where we compared only the PCr\/ATP ratio.<\/p>\n<p><strong>Projects:<\/strong> APVV-24-0504<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter  wp-image-4011\" src=\"https:\/\/www.um.sav.sk\/en\/wp-content\/uploads\/sites\/2\/odd.-04-laci.jpg\" alt=\"\" width=\"855\" height=\"443\" srcset=\"https:\/\/www.um.sav.sk\/en\/wp-content\/uploads\/sites\/2\/odd.-04-laci.jpg 1085w, https:\/\/www.um.sav.sk\/en\/wp-content\/uploads\/sites\/2\/odd.-04-laci-600x311.jpg 600w, https:\/\/www.um.sav.sk\/en\/wp-content\/uploads\/sites\/2\/odd.-04-laci-1024x530.jpg 1024w, https:\/\/www.um.sav.sk\/en\/wp-content\/uploads\/sites\/2\/odd.-04-laci-150x78.jpg 150w, https:\/\/www.um.sav.sk\/en\/wp-content\/uploads\/sites\/2\/odd.-04-laci-768x398.jpg 768w, https:\/\/www.um.sav.sk\/en\/wp-content\/uploads\/sites\/2\/odd.-04-laci-100x52.jpg 100w\" sizes=\"auto, (max-width: 855px) 100vw, 855px\" \/><\/p>\n<p style=\"text-align: center\"><em>Fig. 1: Map of the excitation angle, measured using standard slow signal sampling (one slice per 13 minutes) in panel a), and using fast sampling with a circular trajectory (3D volume per 5 minutes) in panel b).<\/em><\/p>\n<p><strong>Foreign partner:<\/strong> Oxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital, Headington, Oxford, UK, scientific cooperation agreement signed on May 7, 2024.<\/p>\n<p><strong>Publications:<\/strong><\/p>\n<ul>\n<li><u>VALKOVI\u010c, Ladislav<\/u>\u2013 M\u00d3ZES, F.E. \u2013 LYU, Y. \u2013 KARKOURI, J. \u2013 RODGERS, C.T. \u2013 NIESS, F. \u2013 BOGNER, W. \u2013\u00a0<u>SZOMOL\u00c1NYI, Pavol<\/u>.\u00a0<a href=\"https:\/\/doi.org\/10.23919\/MEASUREMENT66999.2025.11078675\">Fast 3D\u00a0<sup>31<\/sup>P B<sub>1<\/sub><sup>+\u00a0<\/sup>mapping using concentric ring trajectory MRSI at 7 T<\/a>. In\u00a0<em>Proceedings of the 15th International Conference on Measurement<\/em>. \u2013 Bratislava : Institute of Measurement Science, SAS, 2025, p. 180-183. ISBN 978-80-69159-01-3<\/li>\n<li>HALLIDAY, B.P. \u2013 OWEN, R. \u2013 RAGAVAN, A. \u2013 SMITH, K.L. \u2013 STATTON, B. \u2013 BERRY, A. \u2013 KASIAKOGIAS, A. \u2013 TSOUMANI, Z. \u2013 SHANMUGNATHAN, M. \u2013 DUNGU, J.N. \u2013 DE MARVAO, A. \u2013 TAYAL, U. \u2013 WARE, J.S. \u2013 O\u2019REGAN, D.P. \u2013 PENNELL, D.J. \u2013 \u00a0CLELAND, J.G.F. \u2013 PRASAD, S.K. \u2013 GREGSON, J. \u2013 MURPHY, M.P. \u2013 RIDER, O. \u2013\u00a0<u>VALKOVI\u010c, Ladislav<\/u>.\u00a0<a href=\"https:\/\/doi.org\/10.1093\/ehjci\/jeaf310\">A double-blind, randomised placebo-controlled trial examining the effect of MitoQ on myocardial energetics in patients with dilated cardiomyopathy<\/a>. In\u00a0<em>European Heart Journal \u2013 Cardiovascular Imaging<\/em>, 2025. ISSN 2047-2404. (6.6 \u2013 IF2024) Q1, D1<\/li>\n<li>GODLEWSKA, B.R. \u2013 SYLVESTER, A.L. \u2013 EMIR, U.E. \u2013 SHARPLEY, A.L. \u2013 CLARKE, W.T. \u2013 WILLIAMS, S.R. \u2013 GON\u00c7ALVES, A.J. \u2013 RAMAN, B. \u2013\u00a0<u>VALKOVI\u010c, Ladislav<\/u>\u2013 COWEN, P.J.\u00a0<a href=\"https:\/\/doi.org\/10.1038\/s41380-025-03108-8\">Brain and muscle chemistry in myalgic encephalitis\/chronic fatigue syndrome (ME\/CFS) and long COVID: A 7T magnetic resonance spectroscopy study<\/a>. In\u00a0<em>Molecular Psychiatry<\/em>, 2025, vol. 30, p. 5215-5226. ISSN 1359-4184. (10.1 \u2013 IF2024) Q1, D1<\/li>\n<li>DEVESA, A. \u2013 DELGADO, V. \u2013\u00a0<u>VALKOVI\u010c, Ladislav<\/u>\u2013 LIMA, J.A.C. \u2013 NAGEL, E. \u2013 IBANEZ, B. \u2013 RAMAN, B.\u00a0<a href=\"https:\/\/doi.org\/10.1161\/CIRCRESAHA.125.325517\">Multiorgan imaging for interorgan crosstalk in cardiometabolic diseases<\/a>. In\u00a0<em>Circulation Research<\/em>, 2025, vol. 136, no. 11, p. 1454-1475. \u00a0ISSN 0009-7330. (16.2 \u2013 IF2024) Q1, D1<\/li>\n<li>THIRUNAVUKARASU, S. \u2013 ANSARI, F. \u2013 KOTHA, S. \u2013 GIANNOUDI, M. \u2013 PROCTER, H. \u2013 CASH, L. \u2013 CHOWDHARY, A. \u2013 JEX, N. \u2013 SHIWANI, H. \u2013 FORBES, K. \u2013\u00a0<u>VALKOVI\u010c, Ladislav<\/u>\u2013 KELLMAN, P. \u2013 PLEIN, S. \u2013 GREENWOOD, J.P. \u2013 EVERETT, T. \u2013 SCOTT, E.M. \u2013 LEVELT, E.\u00a0<a href=\"https:\/\/doi.org\/10.1016\/j.ajog.2024.11.018\">Cardiac structural, functional and energetic assessments during and after pregnancy in women with gestational diabetes mellitus, preeclampsia and healthy pregnancy<\/a>. In\u00a0<em>American Journal of Obstetrics and Gynecology<\/em>, 2025, vol. 232, no. 6, p. 565.e1-565.e16. ISSN 0002-9378. (8.4 \u2013 IF2024) Q1, D1<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Investigators: Ladislav Valkovi\u010d, Pavol Szomol\u00e1nyi Quantifying the concentration of energy metabolites requires accurate measurement of the magnetic field (B1), especially at 7T where the excitation&#8230;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[33,37,30],"tags":[],"class_list":["post-4039","post","type-post","status-publish","format-standard","hentry","category-international-projects","category-mri","category-selected-results"],"publishpress_future_action":{"enabled":false,"date":"2026-05-06 23:57:59","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/posts\/4039","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/comments?post=4039"}],"version-history":[{"count":1,"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/posts\/4039\/revisions"}],"predecessor-version":[{"id":4040,"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/posts\/4039\/revisions\/4040"}],"wp:attachment":[{"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/media?parent=4039"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/categories?post=4039"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/tags?post=4039"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}