{"id":3014,"date":"2022-11-30T13:26:02","date_gmt":"2022-11-30T12:26:02","guid":{"rendered":"https:\/\/www.um.sav.sk\/en\/?p=3014"},"modified":"2023-01-10T09:36:06","modified_gmt":"2023-01-10T08:36:06","slug":"1-exploring-cortical-coding-of-endogenous-chronic-pain-and-effective-pain-relief-strategies","status":"publish","type":"post","link":"https:\/\/www.um.sav.sk\/en\/selected-results\/1-exploring-cortical-coding-of-endogenous-chronic-pain-and-effective-pain-relief-strategies\/","title":{"rendered":"Exploring cortical coding of endogenous chronic pain and effective pain relief strategies"},"content":{"rendered":"<p><span class=\"HwtZe\" lang=\"en\"><span class=\"jCAhz\"><span class=\"ryNqvb\">Investigators: Viktor WITKOVSK\u00dd, Gejza WIMMER, Jr., Laura HAJZOKOV\u00c1 Institute of SAS Measurement, v.v.i. + foreign partners <\/span><\/span><\/span><\/p>\n<p>In collaboration with our partners, we investigated the problem of understanding endogenous chronic pain with the aim of finding and elucidating mechanisms to alleviate suffering. Therefore, we focused on studying the course of brain activity in patients with migraine during the migraine cycle and in patients with chronic back pain. The pathophysiology of migraine as a complex neurological disorder is not yet fully understood, but the clinical signs of the disease, such as cyclic seizure behaviour and vegetative symptoms, suggest a significant role of the hypothalamus. In a longitudinal study, functional magnetic resonance imaging (fMRI) was used to investigate the rhythmicity of cerebral perfusion and hypothalamic connectivity during the migraine cycle. Our results confirm the role of the hypothalamus in the development of migraine attacks. With our approach, we aimed to elucidate how intrinsic functional networks evolve in response to the fluctuating intensity of chronic pain. The observed diversity of individual cortical outcomes of chronic pain encoding supports the understanding of chronic pain as a complex and multilayered condition. An important aspect of our research is the observed variability. We found that there is an individual level of brain modulation in each subject. Our proposed assessment of persistent endogenous pain is a promising tool to assess the patient&#8217;s pain coding and subsequently develop a cognitive strategy for pain relief. The main task of IMS SAS was software development and statistical data analysis using linear mixed effects models.<\/p>\n<p><a href=\"https:\/\/www.um.sav.sk\/vybrane-vysledky\/skumanie-kortikalneho-kodovania-endogennej-chronickej-bolesti-a-efektivnej-strategie-na-ulavu-od-bolesti\/attachment\/witkovsky-2022-aplikacny-typ\/\" rel=\"attachment wp-att-nsm-1-8442\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-nsm-1-8442\" src=\"https:\/\/www.um.sav.sk\/en\/wp-content\/uploads\/Witkovsky-2022-aplikacny-typ.jpg\" alt=\"\" width=\"485\" height=\"323\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p><strong>Fig. 1.<\/strong> <em>Illustration of cortical processing in chronic back pain (CBP). (a) Cortical encoding of endogenous pain intensity. (b) Processing changes in pain intensity. (c) A movement process that requires motor activity and decision making. The graphs on the right show the time dynamics of the hemodynamic delay for several regions in relation to the current pain rating.<\/em><\/p>\n<p>&nbsp;<\/p>\n<h3>Project partners:<\/h3>\n<ul>\n<li>Department of Neurology, LMU University Hospital, Ludwig-Maximilians-Universit\u00e4t, Munich, Germany<\/li>\n<li>Department of Medical Psychology, Ludwig-Maximilians-Universit\u00e4t, Munich, Germany<\/li>\n<li>Department of Clinical Neurosciences, University of Oxford, UK<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Related publications 2021 \/ 2022:<\/h3>\n<p>&nbsp;<\/p>\n<ul>\n<li>JAHN, P. \u2013 DEAK, B. \u2013 MAYR, A. \u2013 STANKEWITZ, A. \u2013 KEESER, D. \u2013 GRIFFANTI, L. \u2013 <u>WITKOVSK\u00dd, Viktor<\/u> \u2013 IRVING, S. \u2013 SCHULZ, E. Intrinsic network activity reflects the ongoing experience of chronic pain. In Scientific Reports, 2021, vol. 11, no. 1, art. no. 21870. ISSN 2045-2322. (4.379 \u2013 IF2020) Q1, D1. Available at: <a href=\"https:\/\/doi.org\/10.1038\/s41598-021-01340-0\">https:\/\/doi.org\/10.1038\/s41598-021-01340-0<\/a><\/li>\n<li>STANKEWITZ, A. \u2013 KEIDEL, L. \u2013 REHM, M. \u2013 IRVING, S. \u2013 KACZMARZ, S. \u2013 PREIBISCH, C. \u2013 <u>WITKOVSK\u00dd, Viktor<\/u> \u2013 ZIMMER, C. \u2013 SCHULZ, E. \u2013 TOELLE, T.R.\u00a0 Migraine attacks as a result of hypothalamic loss of control. In NeuroImage: Clinical, 2021, vol. 32, art. no. 102784. ISSN 2213-1582. (4.881 \u2013 IF2020) Q1, D1. Available at: <a href=\"https:\/\/doi.org\/10.1016\/j.nicl.2021.102784\">https:\/\/doi.org\/10.1016\/j.nicl.2021.102784<\/a><\/li>\n<li>DEAK, B. \u2013 EGGERT, T. \u2013 MAYR, A. \u2013 STANKEWITZ, A. \u2013 FILIPPOPULOS, F. \u2013 JAHN, P. \u2013 <u>WITKOVSK\u00dd, Viktor<\/u> \u2013 STRAUBE, A. \u2013 SCHULZ, E. Intrinsic network activity reflects the fluctuating experience of tonic pain. In Cerebral Cortex, 2022, vol. 32, no. 18, p. 4098\u20134109. ISSN 1047-3211. (4.861 \u2013 IF2021) Q1. Available at: <a href=\"https:\/\/doi.org\/10.1093\/cercor\/bhab468\">https:\/\/doi.org\/10.1093\/cercor\/bhab468<\/a><\/li>\n<li>MAYR, A. \u2013 JAHN, P. \u2013 STANKEWITZ, A. \u2013 DEAK, B. \u2013 WINKLER, A. \u2013 <u>WITKOVSK\u00dd, Viktor<\/u> \u2013 EREN, O. \u2013 STRAUBE, A. \u2013 SCHULZ, E. Patients with chronic pain exhibit individually unique cortical signatures of pain encoding. In Human Brain Mapping, 2022, vol. 43, no. 5, p. 1676-1693. ISSN 1065-9471. (5.399 \u2013 IF2021) Q1. Available at: <a href=\"https:\/\/doi.org\/10.1002\/hbm.25750\">https:\/\/doi.org\/10.1002\/hbm.25750<\/a><\/li>\n<li>MAYR, A. \u2013 JAHN, P. \u2013 DEAK, B. \u2013 STANKEWITZ, A. \u2013 DEVULAPALLY, V. \u2013 <u>WITKOVSK\u00dd, Viktor<\/u> \u2013 DIETRICH, O. \u2013 SCHULZ, E. Individually unique dynamics of cortical connectivity reflect the ongoing intensity of chronic pain. In Pain, 2022, vol. 163, no. 10, p. 1987-1998. ISSN 0304-3959. (7.926 \u2013 IF2021) Q1. Available at: <a href=\"https:\/\/doi.org\/10.1097\/j.pain.0000000000002594\">https:\/\/doi.org\/10.1097\/j.pain.0000000000002594<\/a>. Editor\u2019s Choice \u2013 Video: <a href=\"https:\/\/cdn-links.lww.com\/permalink\/pain\/b\/pain_2022_01_24_schulz_pain-d-21-00996_sdc2.mp4\">https:\/\/cdn-links.lww.com\/permalink\/pain\/b\/pain_2022_01_24_schulz_pain-d-21-00996_sdc2.mp4<\/a><\/li>\n<\/ul>\n<p><span class=\"HwtZe\" lang=\"en\"><span class=\"jCAhz\"><span class=\"ryNqvb\">\u00a0<\/span><\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Investigators: Viktor WITKOVSK\u00dd, Gejza WIMMER, Jr., Laura HAJZOKOV\u00c1 Institute of SAS Measurement, v.v.i. + foreign partners In collaboration with our partners, we investigated the problem&#8230;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[32,30,36],"tags":[],"class_list":["post-3014","post","type-post","status-publish","format-standard","hentry","category-applied-type","category-selected-results","category-theo"],"publishpress_future_action":{"enabled":false,"date":"2026-04-14 02:21:57","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/posts\/3014","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/comments?post=3014"}],"version-history":[{"count":1,"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/posts\/3014\/revisions"}],"predecessor-version":[{"id":3015,"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/posts\/3014\/revisions\/3015"}],"wp:attachment":[{"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/media?parent=3014"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/categories?post=3014"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/tags?post=3014"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}