{"id":1598,"date":"2019-12-16T00:00:42","date_gmt":"2019-12-15T23:00:42","guid":{"rendered":"https:\/\/www.um.sav.sk\/en\/?p=1598"},"modified":"2020-11-09T13:51:18","modified_gmt":"2020-11-09T12:51:18","slug":"1-method-for-measuring-inorganic-phosphate-and-intracellular-ph-in-the-healthy-and-hypertrophic-cardiomyopathy-hearts-by-in-vivo-cardiovascular-magnetic-resonance","status":"publish","type":"post","link":"https:\/\/www.um.sav.sk\/en\/selected-results\/1-method-for-measuring-inorganic-phosphate-and-intracellular-ph-in-the-healthy-and-hypertrophic-cardiomyopathy-hearts-by-in-vivo-cardiovascular-magnetic-resonance\/","title":{"rendered":"Method for measuring inorganic phosphate and intracellular pH in the healthy and hypertrophic cardiomyopathy hearts by in vivo cardiovascular magnetic resonance"},"content":{"rendered":"<p>Investigator: L. Valkovi\u010d<\/p>\n<p>Failing heart is like a pump without fuel; where besides depletion in energy rich metabolites tissue often undergoes acidification. Measurement of intra-myocardial pH using typical magnetic resonance methods hindered by the dominant signal originating in blood that obscures inorganic phosphate (Pi) signal. We have therefore developed a new method using long repetition time and adiabatic excitation at ultra-high field system (7T), which allows, with 100% success rate, Pi detection and therefore pH calculation in human hearts. This method was demonstrated also in a small group of patients with hypertrophied cardiomyopathy, where it showed increased cardiac Pi concentration. This new method will provide answers for numerous clinically relevant questions related to the role of cardiac Pi and pH in cardiovascular and systemic disorders. We have also demonstrated high reproducibility of energy metabolism measurement using 7T MR. Described method will play a pivotal role in future research of cardiac metabolism.<\/p>\n<p><em>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Fig. 1\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Fig. 2<\/em><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-936 aligncenter\" src=\"https:\/\/www.um.sav.sk\/en\/wp-content\/uploads\/sites\/2\/2019_zakladny-vyskum-1-300x133.jpg\" alt=\"\" width=\"467\" height=\"207\" srcset=\"https:\/\/www.um.sav.sk\/en\/wp-content\/uploads\/sites\/2\/2019_zakladny-vyskum-1-300x133.jpg 300w, https:\/\/www.um.sav.sk\/en\/wp-content\/uploads\/sites\/2\/2019_zakladny-vyskum-1-768x340.jpg 768w, https:\/\/www.um.sav.sk\/en\/wp-content\/uploads\/sites\/2\/2019_zakladny-vyskum-1-100x44.jpg 100w, https:\/\/www.um.sav.sk\/en\/wp-content\/uploads\/sites\/2\/2019_zakladny-vyskum-1.jpg 880w\" sizes=\"auto, (max-width: 467px) 100vw, 467px\" \/><\/p>\n<p><strong><em>Fig. 1: <\/em><\/strong><em>A representative fit of a mid-septal spectrum measured during an even acquisition overlaid by the final spectral fit (top); individual peaks fitting (middle) and the residual (bottom) is depicted<\/em><\/p>\n<p><strong><em>Fig. 2: <\/em><\/strong><em>Representative mid-septal spectra with corresponding localizers acquired in a healthy subject (a, c) patients with hypertrophic cardiomyopathy (b, d).<\/em><\/p>\n<p>&nbsp;<\/p>\n<p><strong>Related projects:<\/strong><\/p>\n<ul>\n<li>VEGA 2\/0001\/17 &#8211; Measuring and imaging methods based on magnetic resonance for material and biomedical research<\/li>\n<li>APVV-15-0029 &#8211; Research of comparative imaging methods based on magnetic resonance for diagnostics of neurological and musculoskeletal diseases<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><strong>Publications 2019:<\/strong><\/p>\n<ol>\n<li><u>VALKOVI\u010c, Ladislav<\/u> \u2013 CLARKE, W.T. \u2013 SCHMID, A.I. \u2013 RAMAN, B. \u2013 ELLIS, J. \u2013 WATKINS, H. \u2013 ROBSON, M.D. \u2013 NEUBAUER, S. \u2013 RODGERS, C.T. Measuring inorganic phosphate and intracellular pH in the healthy and hypertrophic cardiomyopathy hearts by in vivo 7T 31P-cardiovascular magnetic resonance spectroscopy. In <em>Journal of Cardiovascular Magnetic Resonance<\/em>, 2019, vol. 21, p. 19. ISSN 1097-6647. (5.070-IF2018), <strong>Q1<\/strong>.<\/li>\n<li>ELLIS, J. \u2013 <u>VALKOVI\u010c, Ladislav<\/u> \u2013 PURVIS, L.A.B. \u2013 CLARKE, W.T. \u2013 RODGERS, C.T. Reproducibility of human cardiac phosphorus MRS (<sup>31<\/sup>P-MRS) at 7 T. In <em>NMR in Biomedicine<\/em>, 2019, vol. 32, no. 6, p. e4095. ISSN 0952-3480. (3.414-IF2018), <strong>Q1<\/strong>.<\/li>\n<li>PURVIS, L.A.B. \u2013 <u>VALKOVI\u010c, Ladislav<\/u> \u2013 ROBSON, M.D. \u2013 RODGERS, C.T. Feasibility of absolute quantification for 31P MRS at 7 T. In <em>Magnetic Resonance in Medicine<\/em>, 2019, vol. 82, no. 1, p. 49-61. ISSN 0740-3194. (3.858-IF2018), <strong>Q1<\/strong>.<\/li>\n<li>SEDIVY, P. \u2013 DEZORTOVA, M. \u2013 RYDLO, J. \u2013 DROBNY, M. \u2013 KR\u0160\u0160\u00c1K, M. \u2013 <u>VALKOVI\u010c, Ladislav<\/u> \u2013 HAJEK, M. MR compatible ergometers for dynamic 31P MRS. In <em>Journal of Applied Biomedicine<\/em>, 2019, vol. 17, no. 2, p. 91-98. ISSN 1214-021X. (1.573-IF2018), <strong>Q2<\/strong>.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Investigator: L. Valkovi\u010d Failing heart is like a pump without fuel; where besides depletion in energy rich metabolites tissue often undergoes acidification. Measurement of intra-myocardial&#8230;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[31,37,30],"tags":[],"class_list":["post-1598","post","type-post","status-publish","format-standard","hentry","category-basic-research","category-mri","category-selected-results"],"publishpress_future_action":{"enabled":false,"date":"2026-04-18 19:21:59","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/posts\/1598","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/comments?post=1598"}],"version-history":[{"count":5,"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/posts\/1598\/revisions"}],"predecessor-version":[{"id":2127,"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/posts\/1598\/revisions\/2127"}],"wp:attachment":[{"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/media?parent=1598"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/categories?post=1598"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.um.sav.sk\/en\/wp-json\/wp\/v2\/tags?post=1598"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}